Maria Branyas Morera, a Spanish supercentenarian, lived to 117 years and 168 days before passing away last year. Born in the United States, she moved to Catalonia in 1915 and spent the rest of her life there, witnessing major historical events including two world wars and 21 U.S. presidencies.

Her extraordinary longevity attracted worldwide interest. Before her death, Maria wished for doctors to study her DNA to help unlock secrets of long life. Researchers from the University of Barcelona and Josep Carreras Leukaemia Research Institute conducted a genetic and cellular health study.

Dr. Manel Esteller, the lead researcher, noted that Maria broke the typical link between aging and illness. Her biological age appeared closer to 100–105, much younger than her actual years. Maria had low levels of harmful cholesterol and triglycerides and unusually high levels of “good” cholesterol, resembling a much younger profile.

Her healthy lifestyle contributed greatly: she exercised regularly, avoided smoking and alcohol, and maintained an active social life. Maria’s daily diet included a smoothie made from eight grains and La Fageda probiotic yogurt, which she credited for her good health due to its inflammation-fighting bacteria.

Scientists also studied Maria’s very short telomeres—normally a sign of aging and higher mortality—but in her case, they may have helped protect against cancer by limiting cell growth.

Maria’s life offers hope that genetics combined with healthy habits might unlock new ways to extend human longevity.